Stanford V is the name of a combination chemotherapy regimen. Unlike most combination regimens, Stanford V is not an acronym.
Stanford V consists of the following drugs:
A Typical Stanford V Regimen (regimens should be tailored to the individual)
- Cycle length: 28 days
- Number of cycles: 3
- Days 1, 15: Doxorubicin (IV push)
- Days 1, 15: Vinblastine (IV push)
- Day 1: Mechlorethamine
- Days 8, 22: Bleomycin and vincristine (IV push)
- Days 15, 16: Etoposide (IV infusion)
- Days 1,3,5,7 … every other day for 28 days: Prednisone (oral)
Vomit potential?
- Day 1: Very high
- Days 8, 22: None
- Day 15: Moderately high
- Day 16: Low
What Stanford V is effective for and why
Stanford V was developed in the early 1990s at Stanford University's Department of Medicine for the treatment of Hodgkin's disease, specifically for patients whose disease is in an advanced stage (III or IV), or patients in stage II but who have bulky mediastinal involvement (a mass in the chest).
The intention of the researchers was to develop a regimen that was both well-tolerated and effective in these patients while attempting to limit their cumulative exposure to the toxicity of the drugs involved. Although used fairly widely, dissent remains as to whether Stanford V is a better regimen than the current gold standard, ABVD.
Stanford V is almost always followed by consolidative radiation to the areas of the body where bulky disease is found.
Stanford V Side effects
Stanford V is a regimen that involves frequent drug administration over a period of time that, compared to standard regimens, is somewhat condensed. Consequently, common side effects to the regimen include neutropenia, anemia, sensory, motor and automatic neuropathy, nausea and/or vomiting.
Sources
- Ko, Andrew H MD et al. 2008. Everyone's Guide to Cancer Therapy, Fifth Ed. Kansas City. Andres McMeel Publishing LLC.
- Boyiadzis, Michael M. et al. Hematology-Oncology Therapy. 2007. New York: McGraw Hill, Medical Publishing Division.
- Lymphoma Information Network: Stanford V
Significant studies relevant to Stanford V treatment
